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Pain Relief That Works®

Find answers to all of your Biofreeze inquiries

Don’t see an answer to your question? Contact us at 1-800-BIOFREEZE. We want to help.

About Biofreeze

Q: How does Biofreeze Professional work?

A: Biofreeze Professional products are classified as topical analgesics, which work through a ‘counter irritant’ mechanism. This means that the menthol in Biofreeze creates a sensation that overrides pain signals to the brain. This process is known as ‘Gate Control Theory’, where nerve impulses from one stimulus block the nerves containing pain signals to the brain. Recent research also suggests that menthol may stimulate cold receptors in the skin that may help regulate pain as well.

Q: Is Biofreeze commonly used?

A: Yes, Biofreeze is the #1 used and recommended topical pain reliever by chiropractors, massage therapists, physical therapists, and podiatrists.

Q: What is cryotherapy?

A: Also known as ‘cold therapy,’ cryotherapy is the application of cold to temporarily relieve pain. The most common form of cryotherapy is ice. Biofreeze Professional produces the same sensation of cold that accompanies icing but without the pain and numbness sometimes associated with ice. Best of all, Biofreeze products allow you to remain active during treatment.

Q: Is Biofreeze registered with the FDA?

A: Yes, the facility that manufactures Biofreeze is registered with the FDA and operates under strict controls to produce a safe and high quality product. Please refer to the National Drug Code number located on your Biofreeze label, which identifies our products to the FDA.

Q: When was Biofreeze invented?

A: Biofreeze was first introduced in 1991 by a scientist that was searching for a way to help his grandmother manage her arthritis pain. Biofreeze’s unique, cooling formulation is also comforting to sore muscles and joint sprains, easing back shoulder and neck pain, reducing painful ankle, knee, hip, and elbow joints and helping to lessen the pain of muscular strain.

In 2016, the original Biofreeze formula was optimized based on scientific research and introduced as Biofreeze Professional. Biofreeze Professional is the Biofreeze that everyone knows and loves but last longer for a better experience.

Q: Does Biofreeze Professional enhance sports performance as a doping agent?

A: Limited research shows that Biofreeze Professional does not enhance an athlete’s sports performance––it is not a performance enhancement drug. However, we do not have clear information on whether or not Biofreeze Professional can cause false positives during various drug tests. This has proven to be a difficult question to answer and the information is anecdotal at best.

Q: Are there scientific studies done on Biofreeze Professional?

A: Yes, Biofreeze conducts all FDA-required studies such as skin sensitization, drug stability, and process validation testing. We also conduct an additional battery of tests in our laboratory. Lastly, we conduct studies with clinicians to further understand our products. These studies can be found at here.

Q: Do you have any studies about long-term use of Biofreeze Professional?

A: Biofreeze Professional is a topical pain reliever, not a cure to an underlying condition. It provides temporary pain relief; there are no studies on the long-term use of Biofreeze Professional. If you have any questions regarding the product or its use, please consult your healthcare professional. If conditions worsen or symptoms persist for more than 7 days, consult a doctor.

Biofreeze Professional ingredients

Q: What is the active ingredient in Biofreeze Professional?

A: The active ingredient in Biofreeze Professional is menthol.

Q: Is there Aspirin in Biofreeze Professional?

A: No

Q: Is there Capsaicin in Biofreeze Professional?

A: No

Q: Does Biofreeze Professional contain gluten, starch, aspirin or nut derivatives?

A: No

Q: Is Biofreeze Professional vegetarian friendly?

A: Yes Biofreeze Professional is vegetarian friendly––no animal products are used in the ingredients. Biofreeze does not use animal testing.

Finding Biofreeze Professional

Q: Where can I buy Biofreeze Professional?

A: Biofreeze Professional products are formulated for authorized distribution through healthcare professionals for the patients, clients and athletes under their care. Find a seller of Biofreeze Professional in your area here.

Q: Do I need a prescription to get Biofreeze Professional?

A: No, you do not need a prescription, nor do you need to be a patient of a healthcare professional in your area to purchase Biofreeze Professional from them. Biofreeze Professional is only available through authorized dealers. Biofreeze Professional is not available through retail outlets or pharmacy locations.

Q: Can you send me a sample of Biofreeze Professional?

A: Free Biofreeze Professional gel sample packets are available through healthcare professionals in the United States, including a brochure about the product and a 3 mL trial packet. To get a free sample, find your nearest sample provider with the Professional Finder.

Q: What sizes of Biofreeze Professional are available to purchase by a patient?

A: Biofreeze Professional is available to patients in a 4 oz Gel Tube, 4 oz Gel Tube with Hands-free Applicator, 4 oz 360° Spray, 3 oz Roll-on, or 3 mL trial packets.

  • The 4 fl oz Biofreeze Gel Tube is particularly well suited for hands-on massage applications of larger muscle areas.

  • The 4 fl oz Biofreeze Gel Tube with Hands-free Applicator allows the user to apply the gel either hands-free or hands-on. The delicate sponge applicator is perfect for even application on sore joints, especially smaller joints like the knuckles.

  • The 3 fl oz Biofreeze Roll-on is a hands-free application with the added benefit of the roller ball that can be used to massage painful muscles and stimulate trigger points in the affected area.

  • The 4 fl oz Biofreeze 360° Spray is hands-free application designed for hard to reach areas and is particularly beneficial for conditions involving minor neck and back pain.

  • The 3 mL packets are available in boxes of 100 and are most commonly used for traveling purposes, when it is inconvenient to carry one of the larger sizes.

Learn more about the Biofreeze family of products here.

Q: Can I buy the larger bottle sizes of Biofreeze Professional?

A: The larger sizes of Biofreeze Professional are designed for in-clinic use. Please consult a healthcare professional regarding the purchase of clinical sizes.

Q: Is Biofreeze Professional available in stores or through the Internet?

A: Biofreeze Professional is sold through healthcare professionals, not in retail stores. Many hands-on healthcare professionals do sell Biofreeze Professional in their offices. To locate a healthcare professional in your area please go to the Professional Finder.

Using Biofreeze Professional

Q: What are the indications and directions for use of Biofreeze Professional Pain Reliever?

A: Biofreeze Professional Pain Reliever provides temporary relief from minor aches and pains of sore muscles and joints associated with simple backache, arthritis, strains, bruises, and sprains. Apply Biofreeze Pain Reliever to the affected area not more than 4 times daily; massage not necessary.

Q: How often can I use Biofreeze Professional?

A: Biofreeze can be used up to four times a day.

Q: How long does Biofreeze Professional last? Does it spoil?

A: Different Biofreeze Professional products have different shelf lives ranging from 2-3 years. The expiration date can be located on your Biofreeze Professional packaging.

Q: Can you develop an unscented version of Biofreeze Professional?

A: Biofreeze Professional contains menthol as its active ingredient (not as a scent). Menthol has a characteristic smell, which typically vanishes within minutes of application. We do not have a product that contains no menthol.

Q: Can I take Biofreeze Professional on an airplane?

A: Yes, you can take the 3 fl oz Roll-on and 3 mL sample packet on an airplane.

Q: Will Biofreeze Professional cause any adverse effects if I am taking other medications?

A: Biofreeze Professional is only a topical pain reliever and has a low potential for absorption. We do suggest that you always check with your healthcare professional before using Biofreeze Professional.

Q: Can I use Biofreeze Professional if I’m pregnant or nursing?

A: Biofreeze Professional has not been tested on pregnant or nursing women. Ask your healthcare professional prior to use.

Q: Can I use a heating pad while also using Biofreeze Professional?

A: No, you should never use a heating pad while using Biofreeze Professional. Biofreeze Professional works by causing a cooling effect, not heat. By using a heating pad in conjunction with Biofreeze Professional, you may cause serious injury to yourself. You may not be able to tell how hot the heating pad is on the problem area, even possibly causing yourself to experience severe blistering.

Q: Can I wrap the area where I have used Biofreeze Professional?

A: No. You should not wrap or bandage the area where Biofreeze Professional is being applied.

Q: Can I use Biofreeze Professional to cool sunburn pain, in a tanning bed or sauna?

A: Biofreeze Professional is not intended for these uses. Please refer to label for proper usage indication.

Q: Can I use Biofreeze Professional on insect bites or for poison ivy?

A: Biofreeze Professional is not intended for these uses. Please refer to label for proper usage indication.

Q: Will Biofreeze Professional work on headaches?

A: Biofreeze Professional is not intended for this use.

Q: Can I use Biofreeze Professional on an open wound or stitches?

A: No, do not apply to wounds or damaged skin.

Q: Can I use Biofreeze Professional if I have diabetes?

A: Generally speaking, Biofreeze is safe to use in patients with diabetes. However, we advise that you consult with your healthcare professional before use.

Q: Can my children use Biofreeze Professional?

A: Biofreeze Professional Gel and Roll-on can be used on children ages 2 years and older. Biofreeze Professional 360° Spray can be used on children ages 12 years and older. If you have any questions about using Biofreeze Professional on your children, check with your pediatrician before use.

Accidents or reactions

Q: My child or pet ate Biofreeze Professional, what do I do?

A: If accidentally ingested by a child (or adult), get medical help or contact a Poison Control Center immediately. For a pet, contact your veterinarian immediately and have the product label available when making the call.

Q: Biofreeze Professional in the EYE – how should I treat this?

A: Rinse your eye with cool (not cold) water or take a cool shower with the shower water hitting your forehead and running down through your eyes. Do this for 15 minutes. If problem persists, see a physician and be sure to take your Biofreeze with you.

Q: After applying Biofreeze Professional, I have developed a rash/irritation on my skin. What should I do?

A: Take a cool to lukewarm bath. Relax for at least 20 minutes. If rash persists, contact your physician.